Proposal of blood volume-corrected model for quantification of regional cerebral blood flow with H215O-PET and its application to AVF

Abstract Purpose  It is generally assumed that vascular tracer activity is negligible in the quantification of regional cerebral blood flow (rCBF) with H215O and positron emission tomography (PET) under normal conditions. We attempted to surpass the assumption of abnormal vascular conditions where the vascular tracer activity is significant by introducing the vascular component into the model.