Blood flow alterations in TNBS-induced colitis: Role of endothelin receptors

Abstract   Objectives:The aim of the present study was to investigate the time dependent changes in hemodynamic parameters and to assess the role of endothelin (ET) receptors in trinitrobenzene sulfonic acid (TNBS) induced colitis. Materials:Inferior mesenteric artery (IMA) hemodynamics, myeloperoxidase activity (MPO) and damage scores were measured immediately or 1, 3, 5 and 14 days after colitis. Treatments: Another group of rats received a nonselective ET receptor antagonist bosentan (30 mg/kg/day), ET-A receptor antagonist BQ485 (60 g/rat/day) or ET-B receptor antagonist BQ788 (60 g/rat/day) prior to and on the 1st, 2nd and 3rd days after TNBS administration.