Effect of indomethacin on cerebral blood flow and development of oxygen convulsions

Abstract  Hyperbaric oxygenation modulates cerebral blood flow affecting the development of oxygen convulsions. Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po2 increased. In rats receiving cyclooxygenase inhibitor indomethacin no convulsions were observed, blood flow and Po2 were lower than in controls. Our results indicate that indomethacin prevents hyperemia and alleviates oxygen convulsions under conditions of hyperbaric oxygenation.